First Game (初陣) is the first episode of the Darwin's Game anime.
- Hamada replaces Hiroyuki as the one to send Kaname the Darwin's Game invitation.
- When someone uses a sigil, their eyes glow.
- A butterfly is shown whenever a player dies.
- Because he is still alive, Hiroyuki helps Kaname fight Banda-kun. However, he dies from a stab wound in the parking garage. In the manga, the police officer helps Kaname escape from the station.
- Katou is removed and is replaced by a man who enjoys the Darwin's Game.
- Tagonaka Yukimasa and Sakaki don't visit Kaname's apartment.
- Rokko is removed and Shuka visits Shibuya before meeting Kaname.